Molecular Formula | C5H12N3O4P |
Molar Mass | 209.14 |
Melting Point | 128-132°C |
Water Solubility | Soluble in water. |
Appearance | Solid |
Color | White |
Merck | 14,4719 |
BRN | 3744619 |
Storage Condition | -20°C |
Sensitive | Hygroscopic |
MDL | MFCD00150816 |
Use | A potent histamine receptor agonist |
In vivo study | Treatment of dogs with Histamine phosphate (0.025 mg/kg) increased basilar artery blood flow to an average of 145 percent of that of the control group. Histamine phosphate injected intravenously in dogs, measured using an electromagnetic flow sensor, significantly increased blood flow in the basilar artery and decreased blood pressure in the femoral artery. Histamine phosphate (4 μg/kg) treatment of unanesthetized sheep resulted in an increase in lymph flow from 6.0 to 27.0(SEM)ml/h. Histamine phosphate (4 μg/kg) treatment of unanesthetized sheep also resulted in increases in lung water, pulmonary vascular resistance, arterial PCO2,pH, and hematocrit, and reduce cardiac output and arterial PO2. There was no significant change in lung lymph flow (QL) and protein concentration (CL) in anesthetized open-chest dogs treated with Histamine phosphate (8.3 mg/kg/min), but after Alloxan treatment, both increased significantly. There was no significant change in pulmonary capillary membrane filtration coefficient (Kf) and maximum capillary pressure (PCcritical) in anesthetized open-chest dogs treated with Histamine phosphate (8.3 mg/kg/min). In unanesthetized intact rats treated with Histamine phosphate (50 mg/kg), acid secretion increased significantly, but pepsin output remained unchanged. Histamine phosphate (50 mg/kg) maximizes gastric acid secretion in unanesthetized intact rats without toxic effects. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
WGK Germany | 3 |
RTECS | NI5425000 |
FLUKA BRAND F CODES | 3-10 |
TSCA | Yes |
HS Code | 29332900 |
Reference Show more | 1. Chen, Ya Li, Jia, Li, Qi, Hao, et al. Study on visual histamine rapid detection test paper [J]. Food Research and Development 2018(18):146-150. 2. Chen xunyun, Ma Qingping, Wang Tao, etc. Study on antitussive, expectorant and antiasthmatic effects of naringin [J]. Science and Technology of food industry, 2014, 35(019):355-358. 3. Gu Yue, Ju AI Chun, Man Shu Li, etc. Safety Evaluation of Yiqi Fumai for injection [J]. Drug evaluation studies, 2018. 4. Peng Wenjing, Xin, Liu, Yan, et al. Effects of ethanol extract of Tilia amurensis on contraction of isolated tracheal smooth muscle in guinea pigs [J]. Chinese Journal of Animal Science and Veterinary Medicine, 2016, 43(006):1572-1578. 5. Adilamu afujiang, masumu akimu, guizilenor Imamu, et al. Study on anti-inflammatory and anti-asthmatic effects of total flavonoids of clematis japonicus [J]. Journal of Xinjiang Medical University, 2016, 39(1). 6. Zhang Rui, Ling-Yu Shuang, Liang He, et al. Preliminary Study on antipruritic effect of ethanol solution of Phellodendron amurense in mice [J]. Journal of Hunan University of Traditional Chinese Medicine, 2018, 038(005):508-512. |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Histamine Phosphate act directly on blood vessels, dilating H1 and H2 receptor-mediated arteries and capillaries. |
Target | Value |